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Index > Protein center > AIMP2(Gene name) > Human
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  • AIMP2 (Gene name),
  • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Protein name ),  AIMP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    AIMP2(PRO0992;JTV1);
    Protein name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 2;
    Alternative:
    Protein JTV-1;Multisynthase complex auxiliary component p38;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
    Function:
    Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
    Protein Attributes:
    Sequence length:
    320
    Sequence:
    50:
    MPMYQVKPYH | GGGAPLRVEL | PTCMYRLPNV | HGRSYGPAPG | AGHVQEESNL | 
    100:
    SLQALESRQD | DILKRLYELK | AAVDGLSKMI | QTPDADLDVT | NIIQADEPTT | 
    150:
    LTTNALDLNS | VLGKDYGALK | DIVINANPAS | PPLSLLVLHR | LLCEHFRVLS | 
    200:
    TVHTHSSVKS | VPENLLKCFG | EQNKKQPRQD | YQLGFTLIWK | NVPKTQMKFS | 
    250:
    IQTMCPIEGE | GNIARFLFSL | FGQKHNAVNA | TLIDSWVDIA | IFQLKEGSSK | 
    300:
    EKAAVFRSMN | SALGKSPWLA | GNELTVADVV | LWSVLQQIGG | CSVTVPANVQ | 
    320:
    RWMRSCENLA | PFNTALKLLK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
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    E2927h
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    96T
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    ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    E2927r
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    Packing:
    96T
    ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
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    E2927m
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    Packing:
    96T
    ELISA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
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    E2927b
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    Packing:
    96T
    CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene."
      Nicolaides N.C. , Kinzler K.W. , Vogelstein B.
      Genomics29:329-334(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-129
      tissue: Lymph.
      tissue: Placenta.
    5. 6.
      "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C. , Yu Y. , Zhang S. , Wei H. , Zhou G. , Ouyang S. , Luo L. , Bi J. , Liu M. , He F.
      Submitted (1998-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-320
      tissue: Fetal liver.
    6. 7.
      "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein."
      Quevillon S. , Robinson J.-C. , Berthonneau E. , Siatecka M. , Mirande M.
      J. Mol. Biol.285:183-195(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KARS
    7. 8.
      "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation."
      Kim M.J. , Park B.-J. , Kang Y.-S. , Kim H.J. , Park J.-H. , Kang J.W. , Lee S.W. , Han J.M. , Lee H.-W. , Kim S.
      Nat. Genet.34:330-336(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FUBP1
    8. 9.
      "Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly."
      Halwani R. , Cen S. , Javanbakht H. , Saadatmand J. , Kim S. , Shiba K. , Kleiman L.
      J. Virol.78:7553-7564(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KARS
    9. 10.
      "Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death."
      Ko H.S. , von Coelln R. , Sriram S.R. , Kim S.W. , Chung K.K.K. , Pletnikova O. , Troncoso J. , Johnson B. , Saffary R. , Goh E.L. , Song H. , Park B.-J. , Kim M.J. , Kim S. , Dawson V.L. , Dawson T.M.
      J. Neurosci.25:7968-7978(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PARK2;UBIQUITINATION
    10. 11.
      "Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro."
      Guzzo C.M. , Yang D.C.H.
      Biochem. Biophys. Res. Commun.365:718-723(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KARS
    11. 12.
      "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53."
      Han J.M. , Park B.-J. , Park S.G. , Oh Y.S. , Choi S.J. , Lee S.W. , Hwang S.-K. , Chang S.-H. , Cho M.-H. , Kim S.
      Proc. Natl. Acad. Sci. U.S.A.105:11206-11211(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53;VARIANTS VAL-92; 97-ASP--SER-99 AND SER-209;MUTAGENESIS OF 163-GLU-ASN-164 AND 172-GLN-ASN-173
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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